Consistent with the general requirements for the submission of cases of suspected adverse reactions, literature cases should be checked to prevent the submission of duplicates ICSRs. It is, therefore, expected that ICSRs are checked in the organisation database to identify literature articles that have already been submitted. Where applicable, this should include ICSRs resulting from the Agency’s Medical Literature Monitoring activities in accordance with Article 27 of Regulation (EC) No 726/2004.